Today, January 29, reports from phase 3 trials of the single-shot Johnson & Johnson adenovirus vaccine, and of the two-shot Novavax protein vaccine were published, and both seem effective (both may be more effective than the two-shot AstraZeneca adenovirus vaccine). Nat probably got a dose of the Novavax two days ago.

Last night I watched the UCSF Virtual Grand Rounds, and Shane Crotty, an immunologist at the La Jolla Institute, presented a lot of background information on the potentially dangerous new virus variants in the UK, South Africa, and Brazil. He was guardedly optimistic that the current formulations of most of the vaccines, together with the resiliency of the human immune response (memory B cells, CD4⁺ T cells, and CD8⁺ T cells, as well as the wide variety of antibodies that arise from exposures) will still work with fairly good efficiency against these new variants. What stood out to me from his presentation was that the physical binding properties of the spike protein in the virus to the ACE2 and other receptors in the body, are not perfect predictors of which virus variants will prove more transmissible, more infectious, or more deadly. Predictions of which variant will predominate, how fast it will take over, and whether we will see the constant evolutionary emergence of more or less dangerous variants, is still a guessing game.

Crotty published a paper in Science: ‘Beyond sterilizing immunity, immune responses that confine SARS-CoV-2 to the URT and oral cavity would minimize COVID-19 disease severity to that of a ‘common cold’ or asymptomatic disease. This outcome is the primary goal of current COVID-19 vaccine clinical trials.’

By this fall, we will know a lot more.

A hopeful prediction from Washington DC in the LA Times for January 22: ‘Fauci provided updates on how scientists are tracking mutations of the virus, and said he hopes to see 70% to 85% of Americans vaccinated by summer’s end. If that happens, he said, “I believe that by the time we get to the fall, we will be approaching a degree of normality. It’s not going to be perfectly normal, but one that I think will take a lot of pressure off the American public.”’

Meanwhile in California, they don’t really know how many people have been vaccinated. On the same day: ‘“This vaccine distribution is being jerry-rigged on a famously fragmented health system and underfunded public health infrastructure, which produces inconsistencies county by county and provider by provider but also problems with getting timely data to see how California as a whole is doing,” said Anthony Wright, executive director of Health Access California and a member of the state’s vaccine advisory committee.’

But now it’s January 28, and at least two seniors have gotten the first dose of Moderna vaccine, thanks to the incredible

• organization (everything at KP has been online for a decade or more so they can predict the numbers they will need–kind of like a universal health care system would),
• planning (setting up cold storage and procuring a large number of doses of vaccine)
• efficiency (“mass” vaccination sites at least a dozen locations within a drive from the Bay Area), and
• generosity (allowing non-KP members like Rachel and former KP members like me to receive no co-pay vaccinations)

of Kaiser Permanente Northern California. Apparently KP Southern California does not have the same quantity of vaccine and is to date still limiting access to people 75 and older, even though the state announced on January 14 that 65 was the new cutoff age. But we two are happy, once having passed the anxiety of two days of wondering whether it would really happen.

Rachel on Tuesday in San Francisco:

Me on Wednesday in Oakland:

We are starting to feel more confident about resuming what were going to be our retired lives, being able to visit our children, travel abroad, museums, dinners, tango, art classes, life.

And this morning, Newsom’s team finally realized how messed up the distribution was in California and cut a deal with Blue Shield (apparently he has some lobbying contacts with them) to run the distribution to counties and hospitals going forward. From the LA Times: ‘The new statewide vaccine distribution network overseen by Blue Shield will comprise a wide variety of locations at which vaccinations will be administered, including pharmacies, community health centers and temporary pop-up locations.’ We will see in a month whether Blue Shield is up to the task–it sounds daunting in a state as big and far-flung as California.

And a final vaccination note, also from the LA Times today. The airline industry (which I have increasingly less empathy for) is asking the WHO to say that passengers with vaccination cards should be able to skip all the quarantining, testing and other requirements for international air travel. Hopefully, WHO will not fall for this pressure without having scientific data indicating that there is a dramatic decline in transmissivity of virus from those who have been vaccinated. Which I hope is the case!

Last week I began French language lessons with the Alliance Française de Santa Rosa. My instructor is a très sympa young woman whose family is from the Charente near Bordeaux. I signed up for level A2, and feel pretty comfortable starting at that level. The words will come back, and I hope the pronunciation will as well. There are two other students in the class who really are A2-ers.

Yesterday was a Sunday, and [my Feldenkrais practitioner] called me at 8 am, waking me out of half sleep. She was alerting us to the availability of COVID-19 vaccine through Kaiser Permanente. I held my silence until 8:45 and then woke Rachel, who took about 30 minutes to realize that getting vaccinated was more important than sleep. The next two hours were spent on the phone with Kaiser, at the end of which we both got appointments for next week, in Oakland for mine, and in San Francisco for Rachel’s. This was all due to the fact that after carefully setting up priority groups 1a, 1b, 1c, and 2 (Rachel and I are in 1c), the CDC and the California director of public health gave up after finding that 65% of vaccine doses were not being administered. And so Newsom opened the shots to all of us over 65 on January 13.

Rachel was so energized by the thought of being released from fear of the virus that she spent the rest of the day spreading the word about the Kaiser vaccinations to a dozen friends, all of whom got appointments within the next three weeks. Only [two friends in Southern California] decided not to run the Kaiser gauntlet, but rather to wait for their doctor to call them when their turn would come.

On Saturday out of boredom we had started thinking about a family Christmas in Hawaii, and found that rooms in Poipu, Kauai were already starting to disappear. So on Sunday, after the vaccine rush, we also started vacation planning for 2021 in a serious manner. Rachel booked a suite of rooms at Kiahuna for the week after Christmas, and I started my usual travel research for our September trip to the East Coast for weddings, and to France for walking with [those SoCal friends]. I am still hoping we can visit Provence and Marseille. There’s a drive between the Dordogne and Provence that goes through the Gorges du Tarn, and a château that we could stay at half-way through the gorge. But we will see; Rachel feels anxious about a long vacation, and we now have the “problem” of an additional two weeks of U.S. travel on this trip, due to a Labor Day wedding of [the daughter of a college classmate] in New York.

Another pandemic activity: massive housecleaning. We sent 40 pairs of shoes and countless jackets, dresses and other hardly-worn clothing to the Goodwill box.

As Congress started a dreary day of hearing objections by Republican members to all six of the states that Trump assumed he won, a process that was expected to take 18 hours or more, the Capitol was invaded by Proud Boys, QAnon following realtors, and other fanatics, after Trump urged them on during a morning rally.

Rachel and I were at home and just happened to see it all begin on C-SPAN, when there was a request for “order in the House,” followed by Nancy Pelosi being quietly escorted out of the chamber without any announced reason, and then… chaos. The horrible invasion persisted for four hours of looting and hooting, in which five people succumbed. In the evening, some, but not all of the Republican Senators who supported the objections gave way, and after voting down the Arizona objection, Biden and Harris’ electors were duly certified by a stone faced Mike Pence and a happy bunch of Democrats.

It was perhaps appropriate that the day before, I crashed Rachel’s car into a mega-truck parked on Magnolia Avenue across from Emporio Rulli. I think it was exhaustion, wine, or espresso taken during the agonizing weeks since November 3rd, when we had nothing on the media besides political craziness, and nothing on the COVID-19 front besides skyrocketing case counts stemming from the Thanksgiving and Christmas holidays. New case counts in Marin County went from 9 on October 15 to 172 today. What a dreadful and dire situation.

Now it’s nearly time for Biden to take office, and the vaccine rollout, broken as it is, is actually happening.